Different effects of chlorpromazine on bleomycin- and epirubicin induced cytotoxicity.
نویسندگان
چکیده
The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.
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ورودعنوان ژورنال:
- Bioscience reports
دوره 10 2 شماره
صفحات -
تاریخ انتشار 1990